Reprinted from Science, (2001). Lyapina S., Cope G., Shevchenko A., Serino G., Tsuge T., Zhou C., Wolf DA., Wei N., Shevchenko A., and Deshaies RJ. Promotion of NEDD8-CUL1 conjugate cleavage by COP9 signalsome. Volume 292, Pages 1382-1385, with permission from Science.

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