While DNA-mediated charge transport has been well established in solution, our understanding of electron transfer at DNA modified electrodes is still in its infancy. Our efforts towards elucidating the underlying electron transfer mechanisms employ a variety of electrochemical techniques, scanning tunneling microscopy, and atomic force microscopy. In the course of these experiments, we are employing various linker-substrate motifs, new synthetic redox active intercalators, and novel passivation methodologies.
We have exploited the exquisite sensitivity of electron transfer on the integrity of the DNA pi-stack to devise technologies able to detect single nucleotides polymorphisms (SNPs). Based on these principles, we are developing a new DNA-based platform for the study of DNA-protein interactions. In turn, this technology will be used to develop electrochemical assays for DNA-binding proteins, chemotherapeutics, and gene analysis.
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