Heath Group
California Institute of Technology

Publications

Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells Qihui Shi, Lidong Qin, Wei Wei, Feng Geng, Rong Fan, Young Shik Shin, Deliang Guo, Leroy Hood, Paul S. Mischel, and James R. Heath PNAS, 109 pg. 419-424 (2012)

High-Density, Multiplexed Patterning of Cells at Single-Cell Resolution for Tissue Engineering and Other Applications Udi Vermesh, Ophir Vermesh, Jun Wang, Gabriel A. Kwong, Chao Ma, Kiwook Hwang, Prof. James R. Heath Angewandte Chem, 50(32) pg. 7378-7380 (2011)

High performance ring oscillators from 10-nm wide silicon nanowire field-effect transistors Ruo-Gu Huang, Douglas Tham, Dunwei Wang and James R. Heath Nano Research, 4(10) pg. 1005-1012 (2011)

A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells Chao Ma, Rong Fan, Habib Ahmad, Qihui Shi, Begonya Comin-Anduix, Thinle Chodon, Richard C Koya, Chao-Chao Liu, Gabriel A Kwong, Caius G Radu, Antoni Ribas, James R Heath Nature Medicine, online publication 5-22-2011

Protein Signaling Networks from Single Cell Fluctuations and Information Theory Profiling Young Shik Shin, F. Remacle, Rong Fan, Kiwook Hwang, Wei Wei, Habib Ahmad, R.D. Levine, and James R. Heath Biophysical Journal, 100(10) pg. 2378-2386 (2011)

Atomic Force Microscopy Characterization of Room-Temperature Adlayers of Small Organic Molecules through Graphene Templating Peigen Cao, Ke Xu, Joseph O. Varghese, and James R. Heath Journal of the American Chemical Society, 2011, 133 (8), pp 2334-2337

A solid-state switch containing an electrochemically switchable bistable poly[n]rotaxane Wenyu Zhang, Erica DeIonno, William R. Dichtel, Lei Fang, Ali Trabolsi, John-Carl Olsen, Diego Benítez, James R. Heath and J. Fraser Stoddart Journal of Materials Chemistry, 2011, 21, 1487-1495

Flow optimization study of a batch microfluidics PET tracer synthesizing device. Elizarov AM, Meinhart C, Miraghaie R, van Dam RM, Huang J, Daridon A, Heath JR, Kolb HC. Biomed Microdevices., 2011 Feb;13(1):231-42.

Ultradense, Deep Subwavelength Nanowire Array Photovoltaics As Engineered Optical Thin Films Douglas Tham and James R. Heath Nano Letters., 2010, 10 (11), pp 4429-4434

A self-powered, one-step chip for rapid, quantitative and multiplexed detection of proteins from pinpricks of whole blood Jun Wang, Habib Ahmad, Chao Ma, Qihui Shi, Ophir Vermesh, Udi Vermesh and James Heath Lab on a Chip, Article in Press (2010)

Batch Fabrication of High-Performance Planar Patch-Clamp Devices in Quartz John M. Nagarah, Eunsu Paek, Yi Luo, Pin Wang, Gyeong S. Hwang, James R. Heath Advanced Materials., Volume 22, Issue 41, pages 4622-4627, November 2, 2010

Graphene Visualizes the First Water Adlayers on Mica at Ambient Conditions Ke Xu, Peigen Cao, James R. Heath Science, 329(5996), 1188-1191 (2010) Perspective article: Just Add Water, M. I. Katsnelson. Science, 329 (5996), 1157-1158 (2010)

Achieving the Theoretical Depairing Current Limit in Superconducting Nanomesh Films Ke Xu, Peigen Cao, and James R. Heath Nano Letters., 2010, 10 (10), pp 4206-4210

Chemistries for Patterning Robust DNA MicroBarcodes Enable Multiplex Assays of Cytoplasm Proteins from Single Cancer Cells Shin YS; Ahmad H; Shi Q; Kim H; Pascal TA; Fan R; Goddard WA III; Heath JR. ChemPhysChem, Volume 11, Issue 14, pages 3063-3069, October 4, 2010

Thermal Conductivity Reduction in Phononic Nanomesh Films. Jen Kan Yu; Mitrovic, S; Tham D; Varghese J; Heath JR Nature Nanotechnology, 5, 718-721 (2010)

Time Resolved Studies of Interfacial Reactions of Ozone with Pulmonary Phospholipid Surfactants Using Field Induced Droplet Ionization Mass Spectrometry Hugh I. Kim, Hyungjun Kim, Young Shik Shin, Luther W. Beegle, William A. Goddard, James R. Heath, Isik Kanik and J. L. Beauchamp The Journal of Physical Chemistry B, 2010, 114 (29), pp 9496-9503

Maximal entropy inference of oncogenicity from phosphorylation signaling T. G. Graeber , J. R. Heath , B. J. Skaggs , M. E. Phelps a, , F. Remacle a, , and R. D. Levine PNAS., March 30, 2010 vol. 107 no. 13 6112-6117

Interfacial Reactions of Ozone with Surfactant Protein B in a Model Lung Surfactant System Hugh I. Kim, Hyungjun Kim, Young Shik Shin, Luther W. Beegle, Seung Soon Jang, Evan L. Neidholdt, William A. Goddard, James R. Heath, Isik Kanik and J. L. Beauchamp Journal of the American Chemical Society, 2010, 132 (7), pp 2254-2263

Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis Arkadij M. Elizarov, R. Michael van Dam, Young Shik Shin, Hartmuth C. Kolb, Henry C. Padgett, David Stout, Jenny Shu, Jiang Huang, Antoine Daridon and James R. Heath The Journal of Nuclear Medicine, February 2010 vol. 51 no. 2 282-287

First Principles Molecular Modeling of Sensing Material Selection for Hybrid Biomimetic Nanosensors. Mario Blanco, Michael C. McAlpine, and James R. Hath Computational Methods for Sensor Material Selection, 1st Edition., 2010, XV, 319 p. 134 illus.

Accurate MALDI-TOF/TOF Sequencing of One-Bead?One-Compound Peptide Libraries with Application to the Identification of Multiligand Protein Affinity Agents Using in Situ Click Chemistry Screenig Su Seong Lee, Jaehong Lim, Sylvia Tan, Junhoe Cha, Shi Yun Yeo, Heather D. Agnew and James R. Heath Analytical Chemistry., 2010, 82 (2), pp 672-679

Scanning Tunneling Microscopy Characterization of the Electrical Properties of Wrinkles in Exfoliated Graphene Monolayers Ke Xu, Peigen Cao, and James R. Heath Nano Letters, 2009, 9 (12), pp 4446-4451

Challenges and Opportunities for Nanoscience and Technology James R. Heath Nanoscience and Technology: A collection of Reviews from Nature Journals, p. xi. 2010

Modular Nucleic Acid Assembled p/MHC Microarrays for Multiplexed Sorting of Antigen-Specific T Cells Gabriel A. Kwong, Caius G. Radu, Kiwook Hwang, Chengyi J. Shu, Chao Ma, Richard C. Koya, Begonya Comin-Anduix, Sine Reker Hadrup, Ryan C. Bailey, Owen N. Witte, Ton N. Schumacher, Antoni Ribas and James R. Heath Journal of the American Chemical Society, 2009, 131 (28), pp 9695-9703

Molecular Electronics James R. Heath Annual Review of Materials Research, Vol. 39: 1-23

The crossover from two dimensions to one dimension in granular electronic materials K. Xu*, L. Qin*, and J. R. Heath Nature Nanotechnology , 4, 368-372 (2009) *denotes equal contribution

Self-Powered Microfluidic Chips for Multiplexed Protein Assays from Whole Blood Lidong Qin, Ophir Vermesh, Qihui Shi, and James R. Heath Lab On A Chip., 2009, 9, 2016

Iterative In Situ Click Chemistry Creates Antibody-like Protein-Capture Agents Heather D. Agnew, Rosemary D. Rohde, Steven W. Millward, Arundhati Nag, Woon-Seok Yeo, Jason E. Hein, Suresh M. Pitram, Abdul Ahad Tariq, Vanessa M. Burns, Russell J. Krom, Valery V. Fokin, K. Barry Sharpless, James R. Heath Angewandte Chemie Internation Edition., Volume 48, Issue 27, pages 4944-4948, June 22, 2009

Free energy barrier for molecular motions in bistable [2]rotaxane molecular electronic devices. Kim H, Goddard WA 3rd, Jang SS, Dichtel WR, Heath JR, Stoddart JF. The Journal of Physical Chemistry A, 2009 Mar 12;113(10):2136-43.

Fast Nonlinear Ion Transport via Field-Induced Hydrodynamic Slip in Sub-20-nm Hydrophilic Nanofluidic Transistors Udi Vermesh, Jang Wook Choi, Ophir Vermesh, Rong Fan, John Nagarah and James R. Heath Nano Letters, 2009, 9 (4), pp 1315-1319

Nanomedicine Targets Cancer James R. Heath, Mark E. Davis and Leroy Hood Scientific American Magazine, February 2009

Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of blood Rong Fan, Ophir Vermesh, Alok Srivastava, Brian K H Yen, Lidong Qin, Habib Ahmad, Gabriel A Kwong, Chao-Chao Liu, Juliane Gould, Leroy Hood & James R Heath Nature Biotechnology, 26, 1373 - 1378 (2008)

Heterogeneous Catalysis through Microcontact Printing Jason M. Spruell, Bonnie A. Sheriff Dr., Dorota I. Rozkiewicz Dr., William R. Dichtel Dr., Rosemary D. Rohde, David N. Reinhoudt, J. Fraser Stoddart Prof., James R. Heath Prof. Angewandte Chemie International Edition, Volume 47, Issue 51, pages 9927-9932, December 8, 2008

Long, Highly-Ordered High-Temperature Superconductor Nanowire Arrays Ke Xu and James R. Heath Nano Letters, 2008, 8 (11), pp 3845-3849

Azidation of Silicon(111) Surfaces Peigen Cao, Ke Xu and James R. Heath Journal of the American Chemical Society, 2008, 130 (45), pp 14910-14911

Kinetic and Thermodynamic Approaches for the Efficient Formation of Mechanical Bonds William R. Dichtel, Ognjen S. Miljani, Wenyu Zhang, Jason M. Spruell, Kaushik Patel, Ivan Aprahamian, James R. Heath and J. Fraser Stoddart Accounts of Chemical Research, 2008, 41 (12), pp 1750-1761

Systems Biology and the Emergence of Systems Medicine N. D. Price, L. B. Edelman, I. Lee, H. Yoo, G. Carlson, D. J. Galas, J. R. Heath, and L. Hood Genomic and Personalized Medicine: From Principles to Practice, pp. 74-86.

Rapid Microwave-Assisted CNBr Cleavage of Bead-Bound Peptides Su Seong Lee, Jaehong Lim, Junhoe Cha, Sylvia Tan and James R. Heath Journal of Combinatorial Chemistry, 2008, 10 (6), pp 807-809

Complementary Symmetry Nanowire Logic Circuits: Experimental Demonstrations and in Silico Optimizations Bonnie A. Sheriff, Dunwei Wang, James R. Heath and Juanita N. Kurtin ACS Nano, 2008, 2 (9), pp 1789-1798

Superlattice Nanowire Pattern Transfer (SNAP) James R. Heath Accounts of Chemical Research, 2008, 41 (12), pp 1609-1617

Peptide?Nanowire Hybrid Materials for Selective Sensing of Small Molecules Michael C. McAlpine, Heather D. Agnew, Rosemary D. Rohde, Mario Blanco, Habib Ahmad, Andreea D. Stuparu, William A. Goddard, III and James R. Heath Journal of the American Chemical Society, 2008, 130 (29), pp 9583-9589

Development of ultra-high density silicon nanowire arrays for electronics applications Dunwei Wang, Bonnie A. Sheriff, Michael McAlpine and James R. Heath Nano Research, Volume 1, Number 1, 9-21

Folding of a donor-acceptor polyrotaxane by using noncovalent bonding interactions Wenyu Zhang, William R. Dichtel, Adam Z. Stieg, Diego Benítez, James K. Gimzewski, James R. Heath, and J. Fraser Stoddart PNAS., May 6, 2008 vol. 105 no. 18 6514-6519

A One pot Synthesis of Constitutionally Unsymmetrical Rotaxanes Using Cu-Catalyzed Azide-Alkyne Cycloadditions J. M. Spruell, W. R. Dichtel, J. R. Heath, and J. F. Stoddart Chemistry - A European Journal, 14 (14), 4168-4177 (2008).

Hall Mobility Measurements and Chemical Stability of Ultrathin, Methylated Si(111)-on-Insulator Films Jonathan E. Green, Shelley J. Wong, and James R. Heath The Journal of Physical Chemistry C, 2008, 112 (13), pp 5185-5189

Controlled Fabrication and Electrical Properties of Long Quasi-One-Dimensional Superconducting Nanowire Arrays Ke Xu and James R. Heath Nano Letters, 2008, 8 (1), pp 136-141

Two-Dimensional Single-Crystal Nanowire Arrays Dunwei Wang Dr., Yuri Bunimovich, Akram Boukai, James R. Heath Prof. Small, Volume 3, Issue 12, pages 2043-2047, December 3, 2007

Rotaxanes and Catenanes by Click Chemistry Ognjen Š. Miljani?, William R. Dichtel, Ivan Aprahamian, Rosemary D. Rohde, Heather D. Agnew, James R. Heath, J. Fraser Stoddart QSAR & Combinatorial Science, Special Issue: Click Chemistry Volume 26, Issue 11-12, pages 1165-1174, December 2007

Nanotechnology and Cancer James R. Heath and Mark E. Davis Annual Review of Medicine, Vol. 59: 251-265

The Emergence of a Coupled Quantum Dot Array in a Doped Silicon Nanowire Gated by Ultrahigh Density Top Gate Electrodes Ke Xu, Jonathan E. Green, J. R. Heath, F. Remacle, and R. D. Levine The Journal of Physical Chemistry C, 2007, 111 (48), pp 17852-17860

Structural and Co-conformational Effects of Alkyne-Derived Subunits in Charged Donor?Acceptor [2]Catenanes Ognjen Š. Miljani?, William R. Dichtel, Saeed I. Khan, Shahab Mortezaei, James R. Heath, and J. Fraser Stoddart Journal of the American Chemical Society, 2007, 129 (26), pp 8236-8246

Silicon Nanowires as Highly Efficient Thermoelectric Materials Akram Boukai, Yuri Bunimovich, Jamil Taher-Kheli, Jen Kan Yu, William Goddard III, and James R. Heath Nature, 451, 168-171 (2008).

Modular Synthesis and Dynamics of a Variety of Donor-Acceptor Interlocked Compounds Prepared by Click Chemistry Adam B. Braunschweig Dr., William R. Dichtel Dr., Ognjen Š. Miljani? Dr., Mark A. Olson, Jason M. Spruell, Saeed I. Khan Dr., James R. Heath Prof. Dr., J. Fraser Stoddart Prof. Dr. Chemistry - An Asian Journal, Volume 2, Issue 5, pages 634-647, May 4, 2007

Highly ordered nanowire arrays on plastic substrates for ultrasensitive flexible chemical sensors Michael C. McAlpine, Habib Ahmad, Dunwei Wang & James R. Heath Nature Materials, 6, 379 - 384 (2007)

Designing bistable [2]rotaxanes for molecular electronic devices William R. Dichtel, James R. Heath, and J. Fraser Stoddart Philosophical Transactions of the Royal Society, (2007) 365, 1607-1625

A Clicked Bistable [2]Rotaxane Ivan Aprahamian, William R. Dichtel, Taichi Ikeda, James R. Heath, and J. Fraser Stoddart Organic Letters, 2007, 9 (7), pp 1287-1290

Materials science: Synergy in a superlattice James R. Heath Nature, 445, 492-493 (1 February 2007)

DNA-Encoded Antibody Libraries: A Unified Platform for Multiplexed Cell Sorting and Detection of Genes and Proteins Ryan C. Bailey, Gabriel A. Kwong, Caius G. Radu, Owen N. Witte, and James R. Heath Journal of the American Chemical Society, 2007, 129 (7), pp 1959-1967

A 160-kilobit molecular electronic memory patterned at 10^11 bits per square centimetre Jonathan E. Green, Jang Wook Choi, Akram Boukai, Yuri Bunimovich, Ezekiel Johnston-Halperin, Erica DeIonno, Yi Luo, Bonnie A. Sheriff, Ke Xu, Young Shik Shin, Hsian-Rong Tseng, J. Fraser Stoddart & James R. Heath Nature, 445, 414-417 (25 January 2007)

Label-Free Nanowire and Nanotube Biomolecular Sensors for in vitro Diagnostics of Cancer and other Diseases James R. Heath Nanobiotechnology II: more concepts and applications, Chapter 12

Quantitative Real-Time Measurements of DNA Hybridization with Alkylated Nonoxidized Silicon Nanowires in Electrolyte Solution Yuri L. Bunimovich, Young Shik Shin, Woon-Seok Yeo, Michael Amori, Gabriel Kwong, and James R. Heath Journal of the American Chemical Society, VOL. 128, NO. 50, 2006

Scanning Tunneling Microscopy and Spectroscopy of Wet-Chemically Prepared Chlorinated Si(111) Surfaces Peigen Cao, Hongbin Yu, and James R Heath The Journal of Physical Chemistry B, 2006, 110 (47), pp 23615-23618

Transport study of a single bismuth nanowire fabricated by the silver and silicon nanowire shadow masks D. S. Choi, A. A. Balandin, M. S. Leung, G. W. Stupian, N. Presser, S. W. Chung, J. R. Heath, A. Khitun and K. L. Wang Applied Physics Letters, 89, 141503 2006

Complementary Symmetry Silicon Nanowire Logic: Power-Efficient Inverters with Gain Dunwei Wang Dr., Bonnie A. Sheriff, James R. Heath Prof. Small, Volume 2, Issue 10, pages 1153-1158, October 2006

Scanning Tunneling Microscopy of Ethylated Si(111) Surfaces Prepared by a Chlorination/ Alkylation Process Hongbin Yu, Lauren J. Webb, Santiago D. Solares, Peigen Cao, William A. Goddard III, James R. Heath, and Nathan S. Lewis The Journal of Physical Chemistry B, 2006, 110, 23898-23903

Efficient Templated Synthesis of Donor?Acceptor Rotaxanes Using Click Chemistry William R. Dichtel, Ognjen Š. Miljani?, Jason M. Spruell, James R. Heath, and J. Fraser Stoddart Journal of the American Chemical Society, 2006, 128 (32), pp 10388-10390

A Non-Oxidative Approach toward Chemically and Electrochemically Functionalizing Si(111) Rosemary D. Rohde, Heather D. Agnew, Woon-Seok Yeo, Ryan C. Bailey, and James R. Heath Journal of the American Chemical Society, 2006, 128 (29), pp 9518-9525

Scanning tunneling spectroscopy of methyl- and ethyl-terminated Si(111) surfaces Yu, Hongbin and Webb, Lauren J. and Heath, James R. and Lewis, Nathan S. Applied Physics Letters, 88 (25). Art. No. 252111

Electrochemical fabrication of conducting polymer nanowires in an integrated microfluidic system Jun Wang, Yuri L. Bunimovich, Guodong Sui, Stavros Savvas, Jinyi Wang, Yaoyao Guo, James R. Heath and Hsian-Rong Tseng Chemical Communications, 2006, 3075-3077

Silicon p-FETs from Ultrahigh Density Nanowire Arrays Dunwei Wang, Bonnie A. Sheriff, and James R. Heath Nano Letters, 2006, 6 (6), pp 1096-1100

Infrared Spectroscopic Characterization of [2]Rotaxane Molecular Switch Tunnel Junction Devices Erica DeIonno, Hsian-Rong Tseng, Desmond D. Harvey, J. Fraser Stoddart, and James R. Heath The Journal of Physical Chemistry B, 2006, 110 (15), pp 7609-7612

Size-Dependent Transport and Thermoelectric Properties of Individual Polycrystalline Bismuth Nanowires A. Boukai, K. Xu, J.?R. Heath Advanced Materials, Volume 18, Issue 7, pages 864-869, April, 2006

Chlorination?Methylation of the Hydrogen-Terminated Silicon(111) Surface Can Induce a Stacking Fault in the Presence of Etch Pits Santiago D. Solares, Hongbin Yu, Lauren J. Webb, Nathan S. Lewis, James R. Heath, and William A. Goddard, III Journal of the American Chemical Society, 2006, 128 (12), pp 3850-3851

Circuit Fabrication at 17 nm Half-Pitch by Nanoimprint Lithography Gun-Young Jung, Ezekiel Johnston-Halperin, Wei Wu, Zhaoning Yu, Shih-Yuan Wang, William M. Tong, Zhiyong Li, Jonathan E. Green, Bonnie A. Sheriff, Akram Boukai, Yuri Bunimovich, James R. Heath, and R. Stanley Williams Nano Letters, 2006, 6 (3), pp 351-354

Nanotechnologies for biomolecular detection and medical diagnostics Mark Ming-Cheng Cheng, Giovanni Cuda, Yuri L Bunimovich, Marco Gaspari, James R Heath, Haley D Hill, Chad A Mirkin, A Jasper Nijdam, Rosa Terracciano, Thomas Thundat and Mauro Ferrari Current Opinion in Chemical Biology, Volume 10, Issue 1, February 2006, Pages 11-19

Ground-State Equilibrium Thermodynamics and Switching Kinetics of Bistable [2]Rotaxanes Switched in Solution, Polymer Gels, and Molecular Electronic Devices Jang Wook Choi, Amar H. Flood, David W. Steuerman, Sune Nygaard, Adam B. Braunschweig, Nicolle N. P. Moonen, Bo W. Laursen, Yi Luo, Erica DeIonno, Andrea J. Peters, Jan O. Jeppesen, Ke Xu, J. Fraser Stoddart, and James R. Heath Chemistry - A European Journal, Volume 12, Issue 1, pages 261-279, December 16, 2005

Spiers Memorial Lecture Molecular mechanics and molecular electronics Robert Beckman, Kris Beverly, Akram Boukai, Yuri Bunimovich, Jang Wook Choi, Erica DeIonno, Johnny Green, Ezekiel Johnston-Halperin, Yi Luo, Bonnie Sheriff, J. Fraser Stoddart and James R. Heath Faraday Discussions, 2006, 131, 9-22

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